Research Articles  
Takashi Miyauchi profil ET-13 HomePage University of Tsukuba
 
    1. Miyauchi T, Ishikawa T, Sugishita Y, Saito A,Goto K.  Effects of capsaicin on nonadrenergic and noncholinergic nerves in the guinea pig atria: Role of calcitonin gene-related peptide as cardiac neurotransmitter. Journal of  Cardiovascular Pharmacology, 10, 675-682, 1987
    2. Miyauchi T, Ishikawa T, Sugishita Y, Saito A, Goto K.  Effects of piperine on calcitonin gene-related peptide (CGRP)-containing nerves in the isolated rat atria. Neuroscience Letters, 91, 222-227, 1988
    3. Tomobe Y, Miyauchi T, Saito A, Yanagisawa M, Kimura S, Goto K, Masaki T.  Effects endothelin on the renal artery from spontaneously hypertensive and Wistar Kyoto rats.  Europian Journal of Pharmacology, 152, 373-374, 1988
    4. Miyauchi T, Sano Y, Hiroshima O, Yuzuriha T, Sugishita Y, Ishikawa T, Saito A, Goto K.  Positive inotropic effects and receptors of calcitonin gene-related peptide (CGRP) in porcine ventricular muscles. Biochemical and Biophysical Research Communications, 155, 289-294, 1988
    5. Miyauchi T, Ishikawa T, Sugishita Y, Saito A, Goto K.  Involvement of calcitonin gene-related peptide in the positive chronotropic and inotropic effects of piperine and development of cross-tachyphylaxis between piperine and capsaicin in the isolated rat atria. Journal of Pharmachology and Experimental Theapeutics, 248, 816-824, 1989
    6. Miyauchi T, Yanagisawa M, Tomizawa T, Sugisita Y, Suzuki N, Fujino M, Ajisaka R, Goto K, Masaki T. Increased plasma concentrations of endothelin-1 and big endothelin-1 in acute myocardial infarction. The Lancet, Ⅱ, 53-54, 1989
    7. Inoue A, Yanagisawa M, Kimura S, Kasuya Y, Miyauchi T, Goto K, Masaki T.The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc. Natl. Acad. Sci. USA, 86, 2863-2867, 1989
    8. Shiba R, Yanagisawa M, Miyauchi T, Isii Y, Kimura S, Uchiyama Y, Masaki T, Goto K.  Elimination of intravenously injected endothelin-1 from the circulation of the rat. Journal of  Cardiovascular Pharmacology, 13, S98-S101, 1989
    9. Miyauchi T, Ishikawa T, Tomobe Y, Yanagisawa M, Kimura S, Sugishita Y, Ito I, Goto K, Masaki T.  Characteristics of pressor response to endothelin-1 in spontaneously hypertensive and Wistar-Kyoto rats. Hypertension, 14, 427-434, 1989
    10. Suzuki N, Matsumoto H, Kitaba C, Yanagisawa M, Miyauchi T, Masaki T, Fujino M.  Immunoreacive endothelin-1 in plasma detected by a sandwich-type enzyme immunoassay. Journal of  Cardiovascular Pharmacology, 13, S151-S152, 1989
    11. Li L, Ishikawa T, Miyauchi T, Yanagisawa M, Kimura S, Goto K, Masaki T.  Pressor response to endothelin in guinea pigs. The Japanese Journal of Pharmacology, 49, 549-552, 1989
    12. Homma S, Miyauchi T, Goto K, Sugishita Y, Sato M, Ohshima N: Vasoconstrictor effects of endothelin-1 on myocardium microcirculation, Microcirculation Annual 1990, Edited by Tsuchiya M, Asano M, Shozawa T, Nihon-Igakukan, 29-30, 1990
    13. Suzuki N, Matsumoto H, Kitaba C, kimura S, Miyauchi T, Fujio M.   A sandwich-type enzyme immunoassay to detect immunoreacive big- endothelin-1 in plasma. Journal of Immunological Methods, 127, 165-170, 1990
    14. Miyauchi T, Tomobe Y, Shiba R, Ishikawa T, Yanagisawa M, Kimura S, Sugishita Y, Ito I, Goto K, Masaki T.  Involvement of endothelin in the regulation of human vascular tonus: potent vasoconstrictor effect and existence in endothelial cells. Circulation, 81, 1874-1880, 1990
    15. Suzuki N, Miyauchi T, Tomobe Y, Matsumoto H, Goto K, Masaki T, Fujino M.  Plasma concentrations of endothelin-1 in spontaneously hypertensive rats. Biochemical and Biophysical Research Communications, 167, 941-947, 1990
    16. Suzuki N, Matsumoto H, Miyauchi T, Goto K, Masaki T, Tsuda M, Fujino M. Endothelin-3 concentrations in human plasma : the increased concentrations in patients undergoing hemodialysis. Biochemical and Biophysical Research Communications, 169, 809-815, 1990
    17. Homma S, Miyauchi T, Sugishita Y, Goto K, Ookawa K, Sato M, Ohshima N: Effects of calcitonin gene-related peptide on coronary microcirculation, Microcirculation Annual 1991, Edited by Tsuchiya M, Asano M, Katori M, Nihon-Igakukan, 111-112, 1991
    18. Yamane K, Kashiwagi H, Suzuki N, Miyauchi T, Yanagisawa M, Goto K, Masaki T.  Eleveted plasma levels of endothelin-1 in progressive systemic scierosis.  Arthritis and Rheumatism, 34, 243-244, 1991
    19. Miyauchi T, Suzuki N, Kurihara T, Yamaguchi I, Sugishita Y, Matsumoto H, Goto K, Masaki T.  Endothelin-1 and endothelin-3 play different roles in acute and chronic alterations of blood pressure in patients with chronic hemodialysis. Biochemical and Biophysical Research Communications, 178, 276-281, 1991
    20. Toyo-oka T, Aizawa T, Suzuki N, Hirata Y, Miyauchi T, Wee Soo Shin, Yanagisawa M, Masaki T, Sugimoto T.  The increased plasma level of endothelin-1 and coronary spasm induction in patients with vasospastic angina pectoris. Circulation, 83, 476-483, 1991
    21. Homma S, Miyauchi T, Goto K, Sugishita Y, Sato M, Oshima N.  Effects of endothelin-1 on coronary microcirculation in isolated beating hearts of rats. Journal of  Cardiovascular Pharmacology, 17, S276-S278, 1991
    22. Miyauchi T, Sugishita Y, Yamaguchi I, Ajisaka R, Tomizawa T, Onizuka M, Matsuda M, Kono I, Yanagisawa M, Goto K, Suzuki N, Matsumoto H, Masaki T.  Plasma concentrations of endothelin-1 and endothelin-3 are altered differently in various pathophysiological conditions in humans. Journal of Cardiovascular Pharmacology, 17, S394-S397, 1991
    23. Onizuka M, Miyauchi T, Morita R, Akaogi E, Mitsui K, Suzuki N, Fujino M, Yanagisawa M, Goto K, Masaki T, Hori M.  Increased plasma concentrations of endothelin-1 during and after pulmonary surgery. Journal of Cardiovascular Pharmacology, 17, S402-S403, 1991
    24. Suzuki N, Matsumoto H, Miyauchi T, Kitada C, Tsud M, Goto K, Masaki T, Fujino M.  Sandwich-enzyme immunoassays for endothelin family peptides. Journal of Cardiovascular Pharmacology, 17, S420-S422, 1991
    25. Miyauchi T, Yanagisawa M, Iida K, Ajisaka R, Suzuki N, Fujino M, Goto K, Masaki T, Sugishita Y.  Age-and sex-related variation of plasma endothelin-1 concentration in normal and hypertensive subjedts. American Heart Journal, 123, 1092-1093, 1992
    26. Homma S, Miyauchi T, Sugishita Y, Goto K, Sato M, Ohshima N.  vasoconstrictor effects of endothelin-1 on myocardium microcirculation studied by the Langendorff perfusion method: Differential sensitivities among microvessels. Microvascular Research, 43, 205-217, 1992
    27. Sugishita Y, Kurihara T, Yamaguchi I, Maeda H, Ishimitsu T, Endo M, Miyauchi T.  The discrepancies between electrical and mechanical contraction times in human heart. Erectrocardiology, 91, 213-216, 1992
    28. Miyauchi T, Sugishita Y, Matsuda M, Sakai H, Suzuki N, Masaki T, Goto K.  Increased plasma concentration of endothelin-1 in cholesterol-fed rats. Atherosclerosis, 93, 257-259, 1992
    29. Miyauchi T, Doi T, Suzuki N, Kakihana M, Yamaguchi I, Sugishita Y, Mitsui T, Hori M,Masaki T, Goto K.  Plasma endothelin-1 concentrations in the coronary sinus in dogs with artificially induced myocardial infarction. Peptides, 13, 1013-1015, 1992
    30. Ishikawa S, Tsukada H, Yuasa H, Fukue M, Wei S, Onizuka M, Miyauchi T, Ishikawa T, Mitsui K, Goto K, Hori M.  Potent vasoconstrictor effects of endothelin-1 and big endothelin-1 in the isolated perfused rabbit lung: big endothelin-1 is converted to endothelin-1 in the pulmonary circulation. Journal of Applied Physiology, 72, 2387-2392, 1992
    31. Onizuka M, Miyauchi T, Mitsui K, Suzuki N, Masaki T, Goto K, Hori M.  Endothelin-1 mediates regional blood flow during and after pulmonary surgery. The Journal of Thoracic and Cardiovascular Surgery, 104, 1696-1701, 1992
    32. Yamane K, Miyauchi T, Suzuki N, Yuhara T, Akama T, Suzuki H, Kashiwagi H.  Significance of plasma endothelin-1 levels in patients with systemic sclerosis. Journal of Rheumatology, 19, 1566-1571, 1992
    33. Goto K, Miyauchi T, Homma S, Oshima N.  Calcitonin gene-related peptide in the regulation of cardiac function. Annals of the New York Academy of Sciences, 657, 194-203, 1992
    34. Onizuka M, Miyauchi T, Mitsui K, Suzuki N, Ueno H, Goto K, Masaki T, Hori M.  Plasma levels of endothelin-1 and thrombin-antithrombin  Ⅲ complex in patients undergoing open-chest surgery. The Journal of Thoracic and Cardiovascular Surgery, 105, 559-560, 1993
    35. Take K, Sato T, Nonoyama T, Miyauchi T, Goto K, Hommura S.  A new model of transient complete obstration of retinal vessels induced by endothelin-1 injection into the posterior vitreous body in rabbits. Graefe’s Archives Clinical and Experimental Ophtalmology, 231, 476-481, 1993
    36. Lasaratos S, Kashimura H, Nakahara A, Fukutomi H, Osuga T, Urushidani T, Miyauchi T, Goto K.  Gastric ulcer induced by submucosal injection of endothelin-1 role of potent vasoconstriction and intraluminal acid. American Journal of Physiology, 265, G491-G498, 1993
    37. Takei K, Sato T, Nonoyama T, Hommura S, Miyauchi T, Goto K.  Analysis of vasocontractile responses to endothelin-1 in rabbit retinal vessels by using an ETA receptor antagonist and an ETB receptor agonist. Life Sciences, 53, PL111-115, 1993
    38. Lazaratos S, Kashimura H, Nakahara A, Fukutomi H, Osuga T, Miyauchi T, Goto K.  Endothelin-1 induced gastric ulcer is attenuated by cetraxate. Life Sciences, 53, PL123-128, 1993
    39. Tsunoda H, Miyauchi T, Fujita K, Kubo T, Goto K.  Mechanism of rat uterine smooth muscle contraction induced by endothelin-1. British Journal of Pharmacology, 110, 1437-1440, 1993
    40. Yorikane R, Miyauchi T, Sakai S, Sakurai T, Yamaguchi I, Sugishita Y, Goto K.  Altered expression of ETB-receptor mRNA in the lung of rats with pulmonary hypertension. Journal of Cardiovascular Pharmacology, 22, S336-S338, 1993
    41. Yorikane R, Sakai S, Miyauchi T, Sakurai T, Sugishita Y, Goto K.  Increased production of endothelin-1 in the hypertrophied rat heart due to pressure overload FEBS Letters, 332, 31-34, 1993
    42. Miyauchi T, Yorikane R, Sakai S, Sakurai T, Okada M, Nishikibe M, Yano M, Yamaguchi I, Sugishita Y, Goto K.  Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension. Circulation Research, 73, 887-897, 1993
    43. Yorikane R, Sakai S, Miyauchi T, Sakurai T, Goto K.  Possible involvement of endothelin-1 in cardiac hypertrophy. Arzneimittel-Forschung, 44(1), 412-415, 1994
    44. Fukuroda T, Kobayashi M, Ozaki S, Yano M, Miyauchi T, Onizuka M, Sugishita Y, Goto K, Nishikibe M.  Endothelin receptor subtypes in human versus rabbit pulmonary arteries. Journal of Applied Physiology, 76, 1976-1982, 1994
    45. Maeda S, Miyauchi T, Goto K, Matsuda M.  Alteration of plasma endothelin-1 by exercise at intensities lower and higher than ventilatory threshold. Journal of Applied Physiology, 77, 1399-1402, 1994
    46. Koyama K, Yamashita M, Miyauchi T, Goto K.  Mechanisms of hypotension in iminoctadine poisoning: pharmacological analysis in rats. European Journal of Pharmacology, 270, 151-155, 1994
    47. Sato T, Takei K, Nonoyama T, Miyauchi T, Goto K, Hommura S.  Increase in choridal blood flow in rabbits with endothelin-1 induced transient complete obstruction of retinal vessels. Graefe’s Archives Clinical and Experimenal Ophtalmology, 233, 425-429, 1995
    48. Miyauchi T, Sakai S, Ihara M, Kasuya Y, Yamaguchi I, Goto K, Sugishita Y.   Increased endothelin-1 binding sites in the cardiac membranes in rats with chronic heart failure. Journal of Cardiovascular Pharmacology, 22, S336-S338, 1993
    49. Ishikawa S, Miyauchi T, Sakai S, Yamaguchi I, Sugishita Y, Goto K.  Elevated plasma endothelin-1 in young patients with pulmonary hypertension due to congenital heart diseases is decreased after successful surgical repair. The Journal of Thoracic and Cardiovascular Surgery, 110, 271-273, 1995
    50. Ishikawa S, Miyauchi T, Ueno H, Ushinohara H, Sagawa K, Fusazaki N, Sunagawa H, Honda S, Sakai S, Yamaguchi I, Goto K, Sugishita Y.  Influence of pulmonary blood pressure and flow on endothelin-1 production in humans. Journal of Cardiovascular Pharmacology, 26, S429-S433, 1995
    51. Sakai S, Yorikane R, Miyauchi T, Sakurai T, Kasuya Y, Yamaguchi I, Sugishita Y, Goto K.  Altered production of endothelin-1 in the hypertrophied rat heart. Journal of Cardiovascular Pharmacology, 26, S452-S455, 1995
    52. Ishikawa S, Miyauchi T, Sakai S, Sunagawa H, Honda S, Maeda S, Matsuda M, Yamaguchi I, Goto K, Sugishita Y.  Plasma endothelin-1 levels after exercise in patients with congenital heart disase. Journal of Cardiovascular Pharmacology, 26, S491-S493, 1995
    53. Maeda S, Miyauchi T, Waku T, KobaY, Kono I, Goto K, Matsuda M.  Plasma endothelin-1 level in athletes after exercise in a hot environment: exercise-induced dehydration contributes to increase in plasma- endothelin-1. Life Sciences, 58, 1259-1268, 1996
    54. Fukuroda T, Ozaki S, Ihara M, Ishikawa K, Yano M, Miyauchi T, Ishikawa S,               Onizuka M, Goto K, Nishikibe M.  Necesity of dual blockade of endothelin ETA and ETB receptor subtypes for antagonism endothelin-1-induced contraction in human bronchi. British Journal of Pharmacology, 117, 995-999, 1996
    55. Sakai S, Miyauchi T, Sakurai T, Yamaguchi I, Kobayashi M, Goto K, Sugishita Y.   Pulmonary hypertension caused by congestive heart failure is markedly ameliorated by chronic application of an endothelin receptor antagonist : increased expression of endothelin-1 mRNA and endothelin-1-like-immunoreacivity in the lung in congestive heart failure in rats. Journal of the American Colledge of Cardiology, 28, 1580-1588, 1996
    56. Sakai S, Miyauchi T, Sakurai T, Kasuya Y, Ihara M, Yamaguchi I, Goto K, Sugishita Y.   Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure; Marked increase in endothelin-1 production in the failing heart. Circulation, 93, 1214-1222, 1996
    57. Miyauchi T, Tomobe Y, Isikawa T, Goto K, Sugishita Y.   Carcitonin gene-related peptide (CGRP) induces more potent vasorelaxation in the resistance portion than in the conduit portion of mesenteric arteries in humans. Peptides, 17, 877-879, 1996
    58. Miyauchi T, Tomobe Y, Isikawa T, Goto K, Sugishita Y.   Vasoconstriction by endothelin-1 in resistance and condult portions of isolated human mesenteric arteries. European Journal of Pharmacology, 303, 193-196, 1996
    59. Sakai S, Miyauchi T, Kobayashi M, Yamaguchi I, Goto K, Sugishita Y.   Inhibition of myocardial endothelin pathway improves long-term survival in heart failure. Nature, 384, 353-355, 1996
    60. Maeda S, Miyauchi T, Sakane M, Saito M, Maki S, Goto K, Matsuda M.  Endothelin-1 production is increased in the circulation of the non-working leg  but not in working changes in distribution of blood flow in muscles? Journal of Applied Physiology, 82, 1107-1111, 1997
    61. Maeda S, Miyauchi T, Goto K, Matsuda M.  Differences in the change in the time course of plasma endothelin-1 and endothelin-3 levels after exercise in humans. Life Sciences, 61, 419-425, 1997
    62. Fujita K, Tsunoda H, Miyauchi T, Sugishita Y, Kubo T, Goto K.  Pregnancy markedly increases endothelin-1-induced contraction and changes receptor subtypes in uterine smooth muscles in humans. American Journal of Physiology, 272, R541-R548, 1997
    63. Kobayashi T, Miyauchi T, Sakai S, Maeda S, Yamaguchi I, Goto K, Sugishita Y.  Down-regulation of ETB receptor, but not ETA receptor, in congestive lung secondary to heart failure: are marked increases in circulating endothelin-1 partly attributable to decreases in lung ETB receptor-mediated clearance of endothelin-1. Life Sciences, 62, 185-193, 1998
    64. Miyauchi T, Kobayashi T, Yamauchi R, Hoshino T, Sakai S, Kikkawa K, Yabana H, Sugishita Y, Murata S, Goto K.  Cloning of hamster preproendothelin-1 cDNA and its expression in the heart. Journal of Cardiovascular Pharmacology, 31, S298-S301, 1998
    65. Sakai S, Miyauchi T, Kobayashi T, Yamaguchi I, Goto K, Sugishita Y.  Altered expression of isoforms of myosin heavy chain mRNA in the failing rat heart is ameriolated by chronic treatment with an endothelin receptor antagonist. Journal of Cardiovascular Pharmacology, 31, S302-S305, 1998
    66. Maeda S, Miyauchi T, Sakai S, Kobayashi T, Goto K, Sugishita Y, Matsuda M.  Endothelin-1 in the heart during exercise. Journal of Cardiovascular Pharmacology, 31, S392-S394, 1998
    67. Sakai S, Miyauchi T, Kobayashi M, Yamaguchi I, Goto K, Sugishita Y.  Distribution of endothelin-1 in the lung of rats with pulmonary hypertension of different etiology. International Journal of Angiology, 7, 160-164, 1998
    68. Ishikawa S, Miyauchi T, Ueno M, Sagawa K, Sakai S, Ushinohama H, Kado H, Sunagawa H, Goto K, Sugishita Y, Honda S.  Abnormal neurohumoral responses to exercise in patients with heart disease: inhibition of an increase in endothelin-1 production during exercise. Journal of Cardiovascular Pharmacology, 31, S406-S411, 1998
    69. Maki S, Miyauchi T, Sakai S, Kobayashi T, Maeda S, Takata Y, Sugiyama F, Fukamizu A, Murakami K, Goto K, Sugishita Y.  Endothelin-1 expression in hearts of transgenic hypertensive mice overexpressing angiotensin Ⅱ. Journal of Cardiovascular Pharmacology, 31, S412-S416, 1998
    70. Kobayashi T, Miyauchi T, Sakai S, Yamaguchi I, Goto K, Sugishita Y.  Endothelin-converting enzyme and angiotensin-converting enzyme in failing hearts of rats with myocardial infarction. Journal of Cardiovascular Pharmacology, 31, S417-S420, 1998
    71. Yamada M, Ishikawa T, Fujimori A, Miyauchi T, Goto K.  Enhanced depressor and hyperemic responses to calcitonin gene-related peptide in spontaneously hypertensive rats. Peptides, 19, 697-701, 1998
    72. Okuda Y, Tsurumaru k, Suzuki S, Miyauchi T, Asano M, Hong Y, Sone H, Fujita R, Mizutani M, Kawakami Y, Nakajima T, Soma M, Matsuo K, Suzuki H, Yamashita K.  Hypoxia and endothelin-1 induce VEGF production in human vascular smooth muscle cells. Life Science, 63, 477-484, 1998
    73. Maeda S, Miyauchi T, Kobayashi T, Goto K, Matsuda M.  Exercise causes tissue-specific enhancement of endothelin-1 mRNA expression in internal organs. Journal of Applied Physiology, 85, 425-431, 1998
    74. Fuji N, Nagashima S, Yukawa K, Miyauchi T, Maki S, Sakai S, Murakami K, Miyazaki H.  Hypotensive effects of an angiotensin Ⅱtype 1 receptor antagonist differ between excercised and sedentary rats aged from 4 to 19 weeks. Japanese Journal of Physiology, 48, 215-218, 1998
    75. Maeda S, Miyauchi T, Sakai S, Kobayashi T, Iemitsu M, Goto K, Sugishita Y, Matsuda M.  Prolonged exercise causes an increase in endothelin-1 production in the heart in rats. American Journal of Physiology, 275, H2105-H2112, 1998
    76. Kobayashi T, Miyauchi T, Sakai S, Kobayashi M, Yamaguchi I, Goto K, Sugishita Y.  Expression of endothelin-1, ETA and ETB receptors, and ECE and distribution of endothelin-1 in failing rat heart. American Journal of Physiology, 276, H1197-H1206, 1999
    77. Yamauchi-Kono R, Miyauchi T, Hoshina T, Kobayashi T, Aihara H, Sakai S, Yabana H, Goto K, Sugishita Y, Murata S.  Role of endothelin in deterioration of heart failure due to cardiomyopathy in hamsters: increase in endothelin-1 production in the heart and beneficial effect of endothelin A receptor antagonist on survival and cardiac function. Circulation, 99, 2171-2176, 1999
    78. Miyauchi T, Masaki T.  Pathophysiology of endothelin in the cardiovascular system. Annual Review of Physiology, 61, 391-415, 1999
    79. Kakinuma Y, Miyauchi T, Kobayashi T, Yuki K, Maeda S, Sakai S, Goto K, Yamaguchi I.  Myocardial expression of endothelin-2 is altered reciprocally to that of endothelin-1 during ischemia of cardiomyocytes in vitro and during heart failure in vivo. Life Sciences, 65, 1671-1683, 1999
    80. Miyauchi T, Goto K.  Heart failure and endothelin receptor antagonists. Trends in Pharmacological Sciences, 20, 210-217, 1999
    81. Ikeda T, Ohta H, Okada M, kawai N, Nakao R, Siegel P, Kobayashi T, Maeda S, Miyauchi T, Nishikibe M.  Pathophysiological roles of endothelin-1 in Dahl salt-sensitive hypertension. Hypertension, 34, 514-519, 1999
    82. Ueno M, Miyauchi T, Sakai S, Kobayashi T, Goto K, Yamaguchi I.  Effects of physiological or pathorogical pressure load in vivo on myocardial expression of ET-1 and receptors. American Journal of Physiology, 277, R1321-R1330, 1999
    83. Miyauchi T, Sugishita Y: Endothelin Antagonism in the Treatment of Heart Failure, Edited by Kitabatake A, Sasayama S, Francis G.S,「Heart Failure; Frontiers in Cardiology」,  Springer-Verlag, 161-174, 2000
    84. Sakai S, Miyauchi T, Yamaguchi I.  Long-term endothelin receptor antagonist administration improves alterations in expression of various cardiac genes in failing myocardium of rats with heart failure. Circulation, 101, 2849-2853, 2000
    85. Pi J, Kumagai Y, Sun G, Yamauchi H, Yoshida T, Iso H, Endo A, Yu L, Yuki K, Miyauchi T, Shimojo N.  Decreased serum concentrations of nitric oxide metabolites amang Chinese in an endemic area of chronic arsenic poisoning in inner Mongolia. Free Radical Biology & Medicine, 28(7), 1137-1142, 2000
    86. Sakai S, Miyauchi T, Hara J, Goto K, and Yamauchi I.  Hypotensive effect of endothelin-1 via endothelin-B-receptor pathway on pulmonary circulation is enhanced in rats with pulmonary hypertension. Journal of Cardiovascular Pharmacology, 36, S95-S98, 2000
    87. Murakoshi N, Miyauchi T, Kakinuma Y, Yuki K, Goto K, and Yamauchi I.  Impainment of cardiac energy metabolism in vivo causes hemodynamic  abnormality and increases cardiac expression of preproendothelin-1 mRNA. Journal of Cardiovascular Pharmacology, 36, S128-S131, 2000
    88. Irukayama-Tomobe Y, Sakai S, Miyauchi T.  Chronic treatment with probucol effectively inhibits progression of pulmonary hypertension in rats. Life Sciences, 67(16), 2017-2023, 2000
    89. Kakinuma Y, Miyauchi T, Yuki K, Murakoshi N, Goto K, and Yamauchi I.  Mitochondrial dysfunction of cardiomyocytes causing impairment of cellular energy metabolism induces apoptosis, and concomitant increase in cardiac endothelin-1 expression. Journal of Cardiovascular Pharmacology, 36, S201-S204, 2000
    90. Yuki K, Miyauchi T, Kakinuma Y, Murakoshi N, Suzuki T, Hayashi J, Goto K, and Yamaguchi I.  Mitochondrial dysfunction increases expression of endothelin-1 and induces apoptosis through caspase-3 activation in rat cardiomyocytes in vitro. Journal of Cardiovascular Pharmacology, 36, S205-S208, 2000
    91. Ueno M, Miyauchi T, Sakai S, Goto K, and Yamaguchi I.  Endothelin-A-receptor antagonist and oral prostacyclin analog are comparably effective in ameliorating pulmonary hypertension and right ventricular hypertrophy in rats. Journal of Cardiovascular Pharmacology, 36, S305-S310, 2000
    92. Miyauchi T, Sato R, Sakai S, Kobayashi T, Ueno M, Kondo H, Kawano S, Goto K, Yamauchi I.  Endothelin-1 and right-sided heart failure in rats: Effects of an endothelin receptor antagonist on the failing right ventricle. Journal of Cardiovascular Pharmacology, 36, S327-S330, 2000
    93. Ikeda T, Ohta H, Okada M, Kawai N, Makao R, Siegl P.K.S, Kobayashi T, Miyauchi T, and Nishikibe M.  Antihypertensive effects of a mixed endothelin-A-and-B-receptor antagonist, J-104132, were augmended in the presense of an AT1-receptor antagonist, MK-954. Journal of Cardiovascular Pharmacology, 36, S337-S341, 2000
    94. Ienitsu M, Miyauchi T, Maeda S, Yuki k, Kobayashi T, Kumagai Y, Shimojo N, Yamauchi I, and Matsuda M.  Intense exercise causes decrease in expression of both endotherial NO synthase and tissue NOX leve in hearts. American Journal of Physiology, 279, R951-R959, 2000
    95. Kobayashi T, Miyauchi T, Iwasa S, Sakai S, Fan J, Nagata M, Goto K, Watanabe T.  Corresponding distributions of increased endothelin-B receptor expression and increased endothelin-1 expression in the aorta of apolipoprotein E-deficient mice with advanced atherosclerosis. Pathology International, 50(12), 929-936, 2000
    96. Lazaratos S, Irukayama-Tomobe Y, Miyauchi T, Goto K, Nakahara A.  Oxygen radicals mediate the final exacerbation of endothelin-1-induced gastric ulcer in rat. European Journal of Pharmacology, 413(1), 121-129, 2001
    97. Suzuki T, Miyauchi T.   A novel pharmacological action of ET-1 to prevent the cytotoxicity of doxorubicin in cardiomyocytes. American Journal of Physiology, 280, R1399-R1406, 2001
    98. Kakinuma Y, Miyauchi T, Yuki K, Murakoshi N, Goto K, Yamaguchi I.  Novel molecular mechanism of increased myocardial endothelin-1 expression in the failing heart involving the transcriptional factor hypoxia-inducible factor-1α induced for impaired myocardial energy metabolism. Circulation, 103(19), 2387-2394, 2001
    99. Kumagai Y, Hayashi T, Miyauchi T, Endo A, Iguchi A, Kiriya-Sakai M, Sakai S, Yuki K, Kikushima M, Shimojo N.  Phenanthraquinone inhibits eNOS activity and suppresses vasorelaxation. American Journal of Physiology, 281(1), R25-R30, 2001
    100. Maeda S, Miyauchi T, Kakiyama T, Sugawara J, Iemitsu M, Irukayama-Tomobe Y, Murakami H, Kumagai Y, Kuno S, Matsuda M.  Effects of exercise training of 8 weeks and detraining on plasma levels of endothelium-derived factors, endothelin-1 and nitric oxide, in healthly young humans. Life Sciences, 69(9), 1005-1016, 2001
    101. Iemitsu M, Miyauchi T, Maeda S, Sakai S, Kobayashi T, Fujii N, Miyazaki H, Matsuda M, Yamaguchi I.  Physiological and pathological cardiac hypertrophy induce different molecular phenotypes in the rat. American Journal of Physiology, 281(6), R2029-R2036, 2001
    102. Yuki K, Suzuki T, Katoh S, Kakinuma Y, Miyauchi T, Mitsui Y.  Endothelin-1 stimulates cardiomyocyte injury during mitochondrial dysfunction in culture. European Journal of Pharmacology, 431(2), 163-170, 2001
    103. Yuki K, Miyauchi T, Kakinuma Y, Murakoshi N, Maeda S, Goto K,Yamaguchi I, Suzuki T.  Endothelin-1 production is enhanced by rotenone, a mitochondrial complex Ⅰ inhibitor, in cultured rat cardiomyocytes. Journal of Cardiovascular Pharmacology, 38(6), 850-858, 2001
    104. Tadano K, Suzuki J, Hanada K, Nakao M, Nakao R, Uehara S, Ohta H, Miyauchi T, Nishikibe M.  Pathophysiological roles of endogenous endothelin-1 in dogs with chronic heart failure produced by rapid right ventricular pacing. The Journal of Pharmacology and Experimental Therapeutics, 298(2), 729-736, 2001
    105. Iwasa S, Fan J, Miyauchi T, Watanabe T.  Blockade of endothelin receptors reduces diet-induced hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice. Pathobiology, 69(1), 1-10, 2001
    106. Ueno M, Miyauchi T, Sakai S, Yamauchi-Kohno R, Goto K, Yamaguchi I.  A combination of oral endothelin-A receptor antagonist and oral prostacyclin analogue is superior to each drug alone in ameliorating pulmonary hypertension in rats. Journal of the American College of Cardiology, 40(1), 175-181, 2002
    107. Sakai S, Miyauchi T, Irukayama-Tomobe Y, Ogata T, Goto K, Yamaguchi I.  Peroxisome proliferator-activated receptor-γ activators inhibit endothelin-1-related cardiac hypertrophy in rats. Clinical Science, 103(Suppl.48), 16S-20S, 2002
    108. Maeda S, Miyauchi T, Iemitsu M, Tanabe T, Yokota T, Goto K, Yamaguchi I.  Effects of exercise training on expression of endothelin-1 mRNA in the aorta of aged rats. Clinical Science, 103(Suppl.48), 118S-123S, 2002
    109. Iemitsu M, Miyauchi T, Maeda S, Tanabe T, Irukayama-Tomobe Y, Goto K, Matsuda M, Yamaguchi I.  Effects of aging and subsequent exercise training on gene expression of endothelin-1 in rat heart. Clinical Science, 103(Suppl.48), 152S-157S, 2002
    110. Kakinuma Y, Miyauchi T, Suzuki T, Yuki K, Murakoshi N, Goto K, Yamaguchi I.  Enhancement of glycolysis in cardiomyocytes elevates endothelin-1 expression through the transcriptional factor hypoxia-inducible factor-1 α. Clinical Science, 103(Suppl.48), 210S-214S, 2002
    111. Ogata T, Miyauchi T, Sakai S, Irukayama-Tomobe Y, Goto K, Yamaguchi I.  Stimulation of peroxisome-proliferator-activated receptor α(PPARα) attenuates cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts, Clinical Science, 103(Suppl.48), 284S-288S, 2002
    112. Murakoshi N, Miyauchi T, Kakinuma Y, Ohuchi T, Goto K, Yanagisawa M, Yamaguchi I.  Vascular endothelin-B receptor system in vivo plays a favorable inhibitory role in vascular remodeling after injury revealed by endothelin-B receptor-knockout mice. Circulation, 106(15), 1991-1998, 2002
    113. Maeda S, Miyauchi T, Iemitsu M, Tanabe T, Irukayama-Tomobe Y, Goto K, Yamaguchi I, Matsuda M.  Involvement of endogenous endothelin-1 in exercise-induced redistribution of tissue blood flow: An endothelin receptor antagonist reduces the redistribution. Circulation, 106(17),2188-2193, 2002
    114. Iemitsu M, Miyauchi T, Maeda S, Tanabe T, Takanashi M, Iru kayama-Tomobe Y, Sakai S, Ohmori H, Matsuda M, Yamaguchi I.  Aging-induced decrease in the PPAR-α level in hearts is improved by exercise training. American Journal of Physiology, 283(5), H1750-H1760, 2002
    115. Miyauchi T, Maeda S, Iemitsu M, Kobayashi T, Kumagai Y, Yamaguchi I, Matsuda M.  Exercise causes a tissue-specific change of  NO production in the kidney and lung. Journal of Applied Physiology Jan, 94(1), 60-68, 2003
    116. Maeda S, Tanabe T, Miyauchi T, Otsuki T, Sugawara J, Iemitsu M, Kuno S, Ajisaka R, Yamaguchi I, Matsuda M.  Aerobic exercise training reduces plasma endothelin-1 concentration in order women. Journal of Applied Physiology Jan, 95, 336-341, 2003
    117. Tanabe T, Maeda S, Miyauchi T, Iemitsu M, Takanashi M, Iru kayama-Tomobe Y, Yokota T, Ohmori H, Matsuda M.  Exercise training improves aging-induced decrease in eNOS expression of the aorta. Acta Physiologica Scandinavica, 178(1), 3-10, 2003
    118. Horigome H, Miyauchi T, Takahashi-Igari M, Maeda S, MatsuiA.  Increased plasma level of endothelin-1 following percutaneous balloon dilation of aortic coarctation in children. European Journal of Pediatrics, 162, 543-544, 2003
    119. Chisaki k, Okuda Y, Suzuki S, Miyauchi T, Soma M, Ohkoshi N, Sone H, Yamada N, Nakajima T.  Eicosapentaenoic acid suppresses basal and insulin-stimulated endothelin-1 production in human endothelial cells. Hypertension Research, 26(8), 655-661, 2003
    120. Iemitsu M, Miyauchi T, Maeda S, Sakai S, Fujii N, Miyazaki H, Kakinuma Y, Matsuda M, Yamaguchi I.  Cardiac hypertrophy by hypertension and exercise training exhibits different gene expression of enzymes in energy metabolism.  Hypertension Research, 26(10), 829-837, 2003
    121. Irukayama-Tomobe Y, Miyauchi T, Sakai S, Kasuya Y, Ogata T, Takanashi M, Iemitsu M, Sudo T, Goto K, Yamaguchi I.  Endothelin-1-induced cardiac hypertrophy is inhibited by activation of peroxisome proliferator-activated receptor-α party via blockade of c-Jun NH2-terminal kinase pathway. Circulation, 109, 904-910, 2004
    122. Iemitsu M, Miyauchi T, Maeda S, Tanabe T, Takanashi M, Matsuda M, Yamaguchi I.  Exercise training improves cardiac function-related gene levels through thyroid hormone receptor signaling in aged rats. American Journal of Physiology, 286, H1696-H1705, 2004
    123. Ogata T, Miyauchi T, Sakai S, Takanashi M, Irukayama-Tomobe Y, Yamaguchi I.  Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-B pathway. Journal of the American College of Cardiology, 43(8), 1481-1488, 2004
    124. JesminS, Togashi H, Mowa NC, Ueno K, Yamaguchi T, Shibayama A, Miyauchi T, Sakuma I, Yoshioka M.  Characterization of regional cerebral blood flow and expression of angiogenic growth factors in the frontal cortex of juvenile male SHRSP and SHR. Brain Research, 1030(2), 172-182, 2004
    125. Goto K, Miyauchi T, Yanagisawa M.  Emergence of clinical applications of endothelin system inhibitors. Journal of Cardiovascular Pharmacology, 44, 13-14, 2004
    126. JesminS, Sakuma I, Togashi H, Yamaguchi T, Ueno K, Yoshioka M, Hattori Y, Kitabatake A, Miyauchi T.  Altered expression of endothelin and its receptors in the brain of SHR-SP at malignant hypertensive stage. Journal of Cardiovascular Pharmacology, 44, S11-S15, 2004
    127. Jesmin S, Sakuma I, Hattori Y, Kitabatake A, Miyauchi T.  The calcium channel antagonist benidipine reduces plasma and cardiac endothelin-1 levels in type Ⅱ diabetic rat model. Journal of Cardiovascular Pharmacology, 44, S49-S53, 2004
    128. Jesmin S, Sakuma I, Togashi H, Yoshioka M, Hattori Y, Kitabatake A, Miyauchi T.  Effects of endothelin receptor antagonist on expression of AT1 and AT2 receptors in the heart of SHR-SP. Journal of Cardiovascular Pharmacology, 44, S59-S63, 2004
    129. Miyauchi T, Fujimori A, Maeda S, Iemitsu M, Sakai S, Shikama H, Tanabe T, Matsuda M, Goto K, Yamaguchi I.  Chronic administration of an endothelin-A receptor antagonist improves exercise capacity in rats with myocardial infarction-induced congestive heart failure. Journal of Cardiovascular Pharmacology, 44, S64-S67, 2004
    130. Jesmin S, Sakuma I, Togashi H, Yoshioka M, Hattori Y, Kitabatake A, Miyauchi T. Effects of endothelin receptors in the brain of SHR-SP and effects of endothelin blocker. Journal of Cardiovascular Pharmacology, 44, S156-S159, 2004
    131. Jesmin S, Sakuma I, Togashi H, Yoshioka M, Hattori Y, Kitabatake A, Miyauchi T. Brain expression of VEGF and its receptors in SHR-SP and effects of an endothelin blocker. Journal of Cardiovascular Pharmacology, 44, S160-S164, 2004
    132. Shimojo N, Miyauchi T, Iemitsu M, Yoko Irukayama-Tomobe, Maeda S, Ohkubo T, Tanaka Y, Goto K, Yamaguchi I.  Effects of medium-chain triglyceride (MCT) application to SHR on cardiac function, hypertrophy and expression of endothelin-1 mRNA and other genes. Journal of Cardiovascular Pharmacology, 44, S181-S185, 2004
    133. Takanashi M, Miyauchi T, kakinuma Y, Goto K, Yamaguchi I.  Establishment of hypoxia inducible factor-1α overexpressing cells that produce endothelin-1. Journal of Cardiovascular Pharmacology, 44, S268-S273, 2004
    134. Ogata T, Miyauchi T, Irrukayama-Tomobe Y, Takanasi M, Goto K, Yamaguchi I.  The peroxisome proliferator-activated receptor-α activator fenofibrate inhibits endothelin-1-induced cardiac fibroblast proliferation. Journal of Cardiovascular Pharmacology, 44, S279-S282, 2004
    135. Maeda S, Iemitsu M, Miyauchi T, Goto K.  Exercise-induced tissue-specific change in gene expression of endothelin-1. Journal of Cardiovascular Pharmacology, 44, S336-S340, 2004
    136. Fujimori A, Miyauchi T, Sakai S, Yuyama H, Iemitsu M, Sanagi M, Sudoh K, Goto K, Shikama H, Yamaguchi I.  YM598, an orally active ETA receptor antagonist, ameliorates the progression of cardiopulmonary changes and both-side heart failure in rats with cor pulmonale and myocardial infarction. Journal of Cardiovascular Pharmacology, 44, S354-S357, 2004
    137. Irrukayama-Tomobe Y, Miyauchi T, Kasuya Y, Sakai S, Goto K, Yamaguchi I.  Activation of peroxisome proliferator-activated receptor-α decreases endothelin-1-induced p38 mitogen-activated protein kinase activation in cardiomyocytes. Journal of Cardiovascular Pharmacology, 44, S358-S361, 2004
    138. Masuzawa K, Miyauchi T, Takanashi M, Ogata T, Yamaguchi I, Goto K.  Effects of endothelin-1 eyedrops on the retina in rats. Journal of Cardiovascular Pharmacology, 44, S421-S425, 2004
    139. Maeda S, Miyauchi T, Iemitsu M, Sugawara J, Nagata Y, Goto K.  Resistance exercise training reduces plasma endothelin-1 concentration in healthy young humans. Journal of Cardiovascular Pharmacology, 44, S443-S446, 2004
    140. Iemitsu M, Miyauchi T, Maeda S, Matsuda M, Goto K, Yamaguchi I.  Time course alteration of endothelin-1 gene expression in the heart during exercise and recovery from post-exercise periods in rats. Journal of Cardiovascular Pharmacology, 44, S447-S450, 2004
    141. Maeda S, Tanabe T, Otsuki T, Sugawara J, Iemitsu M, Miyauchi T, Kuno S, Ajisaka R, Matsuda M.  Moderate regular exercise increases basal production of nitric oxide in elderly women. Hypertension Research, 27(12), 947-953, 2004
    142. Yasumura Y, Miyatake K, Okamoto H, Miyauchi T, Kawana M, Tsutamoto T, Kitakaze M, Matsubara H, Takaoka H, Anzai T, Himeno H, Yokoyama H, Yokoya K, Shintani U, Hashimoto K, Koretsune Y, Nakamura Y, Imai K, Maruyama S, Masaoka Y, Sekiya M, Shiraki T, Shinohara H, Ozono K, Matsuoka T, Miyao Y, Nomura F.  Rationale for the use of combination angiotensin-converting enzyme inhibitor and angiotensin Ⅱ receptor blocker therapy in heart failure. Circulation Journal, 68(4), 361-6, 2004
    143. Maki S, Miyauchi T, Kakinuma Y, Sakai S, Kobayashi T, Sugiyama F, Fukamizu A, Goto K, Yamaguchi I.  The endothelin receptor antagonist ameliorates the hypertensive phenotypes of transgenic hypertensive mice with renin-angiotensin genes and discloses roles of organ specific activation of endothelin system in transgenic mice. Life Sciences, 16; 74(9), 1105-1118, 2004
    144. Maeda S, Iemitsu M, JesminS, Miyauchi T.  Acute exercise causes an enhancement of tissue renin-angiotensin system in the kidney in rats. Acta Physiologica Scandinavica, 185(1), 79-86, 2005
    145. Mowa CN, JesminS, Miyauchi T.  The penis: a new target and source of estrogen in male reproduction. Histology and Histopathology, 21(1), 53-67, 2005
    146. Maeda S, Iemitsu M, JesminS, Miyauchi T, Kuno S, Matsuda M, Tanaka H.  Aortic stiffnes and aerobic exercise : mechanistic insight from microarray analyses. Medicine & Science in Sports & Exercise, 37(10), 1710-1716, 2005
    147. Yang S, Iemitsu M, Shimojo N, Miyauchi T, Amamiya M, Sumi D, HayashiT, Guifan S, Shimojo N, Kumagai Y.  2,4,6,-trinitroluene inhibits endothelial nitric oxide synthase activity and elevates blood pressure in rats. Arch Toxicol, 79, 705-710, 2005
    148. Iemitsu M, Maeda S, Miyauchi T, Matsuda M, Tanaka H. Gene expression profiling of exercise-induced cardiac hypertrophy in rats. Acta Physiol Scand, 185(4), 259-270, 2005
    149. Motoyuki Iemitsu, Seiji Maeda, Takeshi Otsuki, Jun Sugawara, Takumi Tanabe, Subrina Jesmin, Shinya Kuno, Ryuichi Ajisaka, Takashi Miyauchi, Mitsuo Matsuda Polymorphism in Endothelin-Related Genes Limits Exercise-Induced Decreases in Arterial Stiffness in Older Subjects. Hypertension. 47(5), 928-936, 2006
    150. Masuzawa K, Jesmin S, Maeda S, Kaji Y, Oshika T, Hori S, Goto K, Miyauchi T.  An endothelin type A receptor antagonist reverses upregulated VEGF and  ICAM-1 levels in steptozotocin-induced diabetic rat retina. Current Eye Research, 31, 79-89, 2006
    151. Otsuki T, Maeda S, Kesen Y, Yokoyama N, Tanabe T, Sugawara J, Miyauchi T, Kuno S, Ajisaka R, Matsuda M.  Age-regulated reduction of systemic arterial compliance induces excessive myocardial oxygen comsumption during sub-maximal exercise. Hypertension Research, 29(2), 65-73, 2006
    152. Iemitsu M, Maeda S, Otsuki T, Sugawara J, Tanabe T, Jesmin S, Kuno S, Ajisaka R, Miyauchi T, Matsuda M.  Polymorphism in endothelin-regulated genes limits exercise-induced decreases in arterial stiffness in order subjects. Hypertension Research, 47, 928-936, 2006
    153. Jesmin S, Hattori Y, Maeda S, Zaedi S, Sakuma I, Miyauchi T.  Subdepressor dose of benidipine ameriorates diabetic cardiac remodeling accompanied by normalization of upregulated endothelin system in rats. Am J Physiol Heart Circ Physiol, 290, 2146-2154, 2006
    154. Otsuki T, Maeda S, Iemitsu M, Saito Y, Tanimura Y, Ajisaka R, Goto K, Miyauchi T.  Effects of athletic strength and endurance exercise training in young humans on plasma endothelin-1 concentration and arterial distensibility. Experimental Biology and Medicine, 231(6), 789-793, 2006
    155. Iemitsu M, Maeda S, Otsuki T, Goto K, Miyauchi T.  Time course alterations of myocardial endothelin-1 production during the formation of exercise training-induced cardiac hypertrophy. Experimental Biology and Medicine, 231(6), 871-875, 2006
    156. Shimojo N, Jesmin S, Zaedi S, Soma M, Kobayashi T, Maeda S, Yamaguchi I, Goto K, Miyauchi T.  Effect of eicosapentaenoic acid on the different endothelin system components in endothelin-1-induced hypertrophied cardiomyocytes. Experimental Biology and Medicine, 231(6), 888-892, 2006
    157. Jesmin S, Zaedi S, Yamaguchi N, Maeda S, Shimojo N, Masuzawa K, Yamaguchi I, Goto K, Miyauchi T.  Differential effects of selective endothelin type A receptor antagonist on the gene expression of vascular endothelial growth factor and its receptors in streptozotocin-induced diabetic heart. Experimental Biology and Medicine, 231(6), 902-906, 2006
    158. Jesmin S, Zaedi S, Maeda S, Mowa C, Sakuma I, Miyauchi T.  Reversal of elevated cardiac expression of TGF β1 and endothelin-1 in OLETF diabetic rats by long-acting calcium antagonist. Experimental Biology and Medicine, 231(6), 907-912, 2006
    159. Shimojo N, Jesmin S, Zaedi S, Soma M, Kobayashi T, Maeda S, Yamaguchi I, Goto K, Miyauchi T.  EPA effect on NOS gene expression and on NO level in endothelin-1-induced hypertrophied cardiomyocytes. Experimental Biology and Medicine, 231(6), 913-918, 2006
    160. Jesmin S, Zaedi S, Maeda S, Togashi H, Yamaguchi I, Goto K, Miyauchi T.  Endothelin antagonism suppresses plasma and cardiac endothelin-1 levels in SHRSPs at the typical hypertensive stage. Experimental Biology and Medicine, 231(6), 919-924, 2006
    161. Jesmin S, Zaedi S, Maeda S, Yamaguchi I, Goto K, Miyauchi T.  Effects of selective endothelin A receptor antagonist on the expressions of iNOS and eNOS in the heart of early streptozotocin-induced diabetic rats. Experimental Biology and Medicine, 231(6), 925-931, 2006
    162. Shimojo N, Jesmin S, Zaedi S, Soma M, Maeda S, Yamaguchi I, Goto K, Miyauchi T.  Changes in important apoptosis-related molecules in the endothelin-1-induced hypertrophied cardiomyocytes: Effect of the pretreatment with eicosapentaenoic acid. Experimental Biology and Medicine, 231(6), 932-936, 2006
    163. Zaedi S, Jesmin S, Maeda S, Shimojo N, Yamaguchi I, Goto K, Miyauchi T.  Alterations in gene expressions encoding preproET-1 and NOS in pulmonary tissue in endotoxemic rats. Experimental Biology and Medicine, 231(6), 992-996, 2006
    164. Jesmin S, Zaedi S, Yamaguchi N, Maeda S, Yamaguchi I, Goto K, Miyauchi T.  Effects of dual endothelin receptor antagonist on antiapoptotic marker Bcl-2 expression in streptozotocin-induced diabetic rats. Experimental Biology and Medicine, 231(6), 1034-1039, 2006
    165. Maeda S, Jesmin S, Iemitsu M, Otsuki T, Matsuo T, Ohkawara K, Nakata Y, Tanaka K, Goto K, Miyauchi T.  Weight loss reduces plasma endothelin-1 concentration in obese men. Experimental Biology and Medicine, 231(6), 1044-1047, 2006
    166. Shimojo N, Jesmin S, Zaedi S, Maeda S, Gando S, Yamaguchi I, Goto K, Miyauchi T.  Alterations of gene expressions of preproET-1 and ET receptors in brains of endotoxemic sprague-dawley rats. Experimental Biology and Medicine, 231(6), 1058-1063, 2006
    167. Masuzawa K, Jesmin S, Maeda S, Kaji Y, Oshika T, Zaedi S, Shimojo N, Yaji N, Miyauchi T, Goto K.  A model of retinal ischemia-reperfusion injury in rats by subconjunctival injection of endothelin-1. Experimental Biology and Medicine, 231(6), 1085-1089, 2006
    168. Masuzawa K, Jesmin S, Maeda S, Zaedi S, Shimojo N, Miyauchi T, Goto K.  Effect of endothelin dual receptor antagonist on VEGF levels in streptozotocin-induced diabetic rat retina. Experimental Biology and Medicine, 231(6), 1090-1094, 2006
    169. Zaedi S, Jesmin S, Yamaguchi N, Shimojo N, Maeda S, Gando S, Yamaguchi I, Goto K, Miyauchi T.  Altered expression of endothelin, vascular endothelial growth factor, and its receptor in hepatic tissue in endotoxemic rat. Experimental Biology and Medicine, 231(6), 1182-1186, 2006
    170. Ueno M, Kakinuma Y, Yuhki K, Murakoshi N, Iemitsu M, Miyauchi T, Yamaguchi Y.Doxorubicin induces apoptosis by activasion of caspase-3 in cultured cardiomyocytes in vitro and rat cardiac ventricles in vivo. Journal of Pharmacological Society, 101, 151-158, 2006
    171. Iemitsu M, Maeda S, Jesmin S, Otsuki T, Kasuya Y, Miyauchi T.  Activation pattern of MAPK signaling in the hearts of trained and untrained rats following a single bout of exercise. J appl Physiol, 101, 151-163, 2006
    172. Iemitsu M, Maeda S, Jesmin S, Otsuki T, Miyauchi T.  Exercise training improves aging-induced downregulation of VEGF angiogenic signaling cascade in hearts. Am J Physiol Heart Circ Physiol, 291, 1290-1298, 2006
    173. Otsuki T, Maeda S, Iemitsu M, Jesmin S, Miyauchi T.  Basal gene expression of vascular endothelial growth factor-related transcriptional factors in rat skeletal muscle differs between slow and fast fiber types. Jpn. J. Phys. Fitness Sports Med, 55, 65-70, 2006
    174. Otsuki T, Maeda S, SugawaraJ, Kesen Y, Murakami H, Tanabe T, Miyauchi T, Kuno S, Ajisaka R, Matsuda M.  Age-related reduction of systemic arterial compliance relates to decreased aerobic capacity during sub-maximal exercise. Hypertents Res, 29(10), 759-765, 2006
    175. Shimojo N, JesminS, Zaedi S, Maeda S, Soma M, Aonuma K, Yamaguchi I, Miyauchi T.  Eicsapentaenoic acid prevents endothelin-1-induced cardiomyocyte hypertrophy in vitro through the suppression of TGF-β1 and phosphorylated JNK. Am J Physiol Heart Circ Physiol, 291, 835-845, 2006
    176. Iemitsu M, Maeda S, Miyauchi T, Kuno S, Murakami K, Matsuda M.  Gene expression profiling of exercise training –induced cardiovascular adaptations molecular insight from microarray analyses. International Journal of Sport and Health Sciences, 4, 451-459, 2006
    177. Jesmin S, Miyauchi T, Goto K, Yamaguchi I.  Down-regulated VEGF expression in the diabetic heart is normalized by an endothelin ETA receptor antagonist. Eur J Pharmacol, 542, 184-185, 2006
    178. Yamaguchi N, Jesmin S, Zaedi S, Shimojo N, Maeda S, Gando S, Koyama A, Miyauchi T.  Time-dependent expression of renal vaso-regulately molecules in LPS-induced endotoxema in rat. Peptides, 27(9), 2258-2270, 2006
    179. Sugawara J, Komine H, Hayashi K, Yoshizawa M, Yokoi T, Otsuki T, Shimojo N, Miyauchi T, Maeda S, Tanaka H.  Effect of systemic nitric oxide synthase inhibition on arterial stiffness in humans. Hypertension Res, 30(5), 411-415, 2007
    180. Hayashi K, Maeda S, Iemitsu M, Otsuki T, Sugawara J, Tanabe T, Miyauchi T, Kuno S, Ajisaka R, Matsuda M.  Sex differences in the relationship between estrogen receptor alpha gene polymorphisms and arterial stiffness in order humans. Am J Hypertens, 20(6), 650-656, 2007
    181. Sugawara J, Komine H, Hayashi K, Yoshizawa M, Otsuki T, Shimojo N, Miyauchi T, Yokoi T, Maeda S, Tanaka H.  Systematic (alpha)-adrenergic and nitric oxide inhibition on basal limid blood flow : effects of endurance training in middle-aged amd older adults. Am J Physiol Heart Circ Physiol, 293(3), 1466-1472, 2007
    182. Shimjo N, Jesmin S, Zaedi S, Otsuki T, Maeda S, Yamaguchi N, Aonuma K, Hattori Y, Miyauchi T.  Conributory role of VEGF overexpression in endothelin-1-induced cardiomyocyte hypertrophy. Am J Physiol Heart Circ Physiol, 293(1), 474-481, 2007
    183. Otsuki T, Maeda S, Iemitsu M, Saito Y, Tanimura Y, Sugawara J, Ajisaka R, Miyauchi T.  Postexercise heart rate recovery accelerates in strength-trained athletes. Med Sci Sports Exerc, 39(2), 365-370, 2007
    184. Jesmin S, Zaedi S, Shimjo N, Iemitsu M, Masuzawa K, Yamaguchi N, Mowa CN, Maeda S, Hattori Y, Miyauchi T.  Endothelin antagonism normalizes VEGF signaling and cardiac function in STZ-induced diabetic rat hearts. Am J Physiol Endocrino Metab, 292(4), 1030-1040, 2007
    185. Aizawa K, Iemitsu M, Maeda S, Jesmin S, Otsuki T, Mowa CN, Miyauchi T, Mesaki N.  Expression of steroidogenic enzymes and synthesis of sex steroid hormones from DHEA in skeletal muscle of rats. Am J Physiol Endocrino Metab, 292(2), 577-584, 2007
    186. Otsuki T, Maeda S, Iemitsu M, Saito Y, Tanimura Y, Ajisaka R, Miyauchi T.  Vascular endothelin-derived factors and arterial stiffness in strength-and endurance-trained men. Am J Physiol Heart Circ Physiol, 292(2), 786-791, 2007
    187. Otsuki T, Maeda S, Iemitsu M, Saito Y, Tanimura Y, Ajisaka R, Miyauchi T.  Relationship between arterial stiffness and athletic training programs in young adult men. Am J Hypertens, 20(9), 967-973, 2007
    188. JesminS, Maeda S, Mowa CN, Zaedi S, Togashi H, Prodhan SH, Yamaguchi T, Yoshioka M, Sakuma I, Miyauchi T, Kato N.  Antagonism of endothelin action normalizes altered levels of VEGF and its signaling in the brain of stroke-prone spontaneously hypertensive rat. Eur Pharmacol, 574(2-3), 158-171, 2007
    189. Aizawa K, Iemitsu M, Otsuki T, Maeda S, Miyauchi T, Mesaki N.  Sex differences in steroidogenesis in skeletal muscle following a single bout of exercise in rats. J Apple Physiol, 104(1), 67-74, 2008
    190. Yamashita T, Ohneda O, Nagano M, Iemitsu M, Makino Y, Tanaka H, Miyauchi T, Goto K, Ohneda K, Fuji-Kuriyama Y, Poellinger L, Yamamoto M.  Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein in NEPAS. Mol Cell Biol, 28(4), 1285-1297, 2008
    191. Hayashi K, Maeda S, Iemitsu M, Otsuki T, Sugawara J, Tanabe T, Miyauchi T, Kuno S, Ajisaka R, Matsuda M.  Estrogen receptor-alpha genotype affects exercise-related reduction of arterial stiffness. Med Sci Sport Exerc, 40(2), 252-257, 2008
    192. Iemitsu M, Shimojo N, Maeda S, Irukayama-Tomobe Y, Sakai S, Ohkubo T, Tanaka Y, Miyauchi T.  The benefit of medium-chain triglyceride therapy on the cardiac function of SHRs is associated with a reversal of metabolic and signaling alterations. Am J Physiol Heart Circ Physiol, 295(1), 136-144, 2008
    193. Otsuki T, Maeda S, Iemitsu M, Saito Y, Tanimura Y, Ajisaka R, Miyauchi T.  Systematic arterial compliance, systemic vascular resistance, and effective arterial elastance during exercise in endurance-trained men. Am J Physiol Regul Integr Comp Physiol, 295(1), 228-235, 2008
    194. Sugawara J, Komine H, Hayashi K, Yoshizawa M, Otsuki T, Shimojo N, Miyauchi T, Yokoi T, Maeda S, Tanaka H.  Reduction in alpha-adrenergic receptor-mediated vascular tone contributes to improved arterial compriance with endurance training. Int J Cardiol, 2008
    195. Maeda S, Sugawara J, Yoshizawa M, Otsuki T, Shimojo N, Jesmin S, Ajisaka R, Miyauchi T, Tanaka H.  Involvment of endothelin-1 in habitual exercise-induced increase in arterial compliance. Acta Physiologica, 196(2), 223-229, 2009
    196. Jesmin S, Gando S, Zaedi S, Prodhan SH, Sawamura A, Miyauchi T, Hiroe M, Yamaguchi N.  Protease-activated receptor 2 blocking peptide counteracts endothelin-induced inflammation and coagulation and ameliorates renal fibrin. Shock, 32(6), 626-632, 2009
    197. Satoshi Sakai, Taizo Kimura, Zheng Wang, Nobutake Shimojo, Hidekazu Maruyama, Satoshi Homma, Keisuke Kuga, Iwao Yamaguchi, Kazutaka Aonuma, Takashi Miyauchi.  Endothelin-1-induced cardiomyocyte hypertrophy is partly regulated by transcription factor Ⅱ-F interacting C-terminal domain phosphatase of RNA polymerase Ⅱ.  Life Sciences, 91, 572-577, 2012
    198. Yumi Miyauchi, Satoshi Sakai, Seiji Maeda, Nobutake Shimojo, Shigeyuki Watanabe, Satoshi Homma, Keisuke Kuga, Kazutaka Aonuma, Takashi Miyauchi.Increased plasma levels of big-endothelin-2 and big-endothelin-3 in patients with end-stage renal disease. Life Sciences, 91, 729-732, 2012
    199. Vignon-zellweger N, Heiden S, Miyauchi T, Emoto N.   Endothelin and endothelin receptors in the renal and cardiovascular systems. Life Sciences, 91(13-14), 490-500, 2012
    200. Tomoko Yokota, Hiroyasu Akatsu, Takashi Miyauchi, Klaus Heese.   Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer’s disease brain. FEBS Letters, 586 (4357–4361), 2012
    201. Miyauchi T and Goto K. Endothelins. ( Edited by Abba J. Kastin ) 「Handbook of Biologically Active Peptides ( Second Edition ) 」, Academic Press ( Elsevier Inc. ) ,  Chapter 190, pp 1402 - 1407, 2013
 
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